Library / N–3 Fatty Acids in Patients with Multiple Cardiovascular Risk Factors


The authors claim that treatment with n−3 polyunsaturated fatty acid does not reduce the risk of heart attacks.

  • Double-blind, placebo-controlled clinical trial
  • Decent sample size: 1383 events; 11200 patients
  • Claimed power: 90%
  • Detailed results, confidence intervals are provided
  • I found protocol here, but it’s in Italian.
  • I’ve found the raw data

Discussed in Statistics Done Wrong (page 84).

Reference

“n–3 Fatty Acids in Patients with Multiple Cardiovascular Risk Factors” (2013) // New England Journal of Medicine. Publisher: Massachusetts Medical Society. Vol. 368. No 19. Pp. 1800–1808. DOI: 10.1056/nejmoa1205409

Bib

@Article{d101056nejmoa1205409_2013,
  title = {n–3 Fatty Acids in Patients with Multiple Cardiovascular Risk Factors},
  volume = {368},
  issn = {1533-4406},
  url = {http://dx.doi.org/10.1056/NEJMoa1205409},
  doi = {10.1056/nejmoa1205409},
  number = {19},
  journal = {New England Journal of Medicine},
  publisher = {Massachusetts Medical Society},
  year = {2013},
  month = {may},
  pages = {1800–1808}
}

References (1)

  1. Statistics Done Wrong (2015) by Alex Reinhart 13 4 Mathematics Statistics Science Audit
  1. Efficacy of n-3 Polyunsaturated Fatty Acids and Feasibility of Optimizing Preventive Strategies in Patients at High Cardiovascular risk (2010) Has notes 2 Medicine Incorrect