Library / Efficacy of n-3 Polyunsaturated Fatty Acids and Feasibility of Optimizing Preventive Strategies in Patients at High Cardiovascular risk: Rationale, Design and Baseline Characteristics of the Rischio and Prevenzione study, a Large Randomised Trial in General Practice


The authors claim that treatment with n−3 polyunsaturated fatty acid reduces the risk of heart attacks. The claim has been made using observational research without accounting for multiple confounding factors. Correlation does not imply causation.

In d101056nejmoa1205409_2013 (double-blind, placebo-controlled clinical trial), a similar study shows that there is no effect.

Discussed in Statistics Done Wrong (page 84).

Reference

“Efficacy of n-3 polyunsaturated fatty acids and feasibility of optimizing preventive strategies in patients at high cardiovascular risk: rationale, design and baseline characteristics of the Rischio and Prevenzione study, a large randomised trial in general practice” (2010) // Trials. Publisher: Springer Science and Business Media LLC. Vol. 11. No 1. DOI: 10.1186/1745-6215-11-68

Bib

@Article{d101186174562151168_2010,
  title = {Efficacy of n-3 polyunsaturated fatty acids and feasibility of optimizing preventive strategies in patients at high cardiovascular risk: rationale, design and baseline characteristics of the Rischio and Prevenzione study, a large randomised trial in general practice},
  volume = {11},
  issn = {1745-6215},
  url = {http://dx.doi.org/10.1186/1745-6215-11-68},
  doi = {10.1186/1745-6215-11-68},
  number = {1},
  journal = {Trials},
  publisher = {Springer Science and Business Media LLC},
  year = {2010},
  month = {may}
}

References (2)

  1. N–3 Fatty Acids in Patients with Multiple Cardiovascular Risk Factors (2013) Has notes 1 1 Medicine Decent
  2. Statistics Done Wrong (2015) by Alex Reinhart 13 4 Mathematics Statistics Science Audit