Reference
John PA Ioannidis, Thomas A Trikalinos “Early extreme contradictory estimates may appear in published research: The Proteus phenomenon in molecular genetics research and randomized trials” (2005) // Journal of Clinical Epidemiology. Publisher: Elsevier BV. Vol. 58. No 6. Pp. 543–549. DOI: 10.1016/j.jclinepi.2004.10.019
Bib
@Article{ioannidis2005b,
title = {Early extreme contradictory estimates may appear in published research: The Proteus phenomenon in molecular genetics research and randomized trials},
volume = {58},
issn = {0895-4356},
url = {http://dx.doi.org/10.1016/j.jclinepi.2004.10.019},
doi = {10.1016/j.jclinepi.2004.10.019},
number = {6},
journal = {Journal of Clinical Epidemiology},
publisher = {Elsevier BV},
author = {Ioannidis, John PA and Trikalinos, Thomas A},
year = {2005},
month = {jun},
pages = {543–549}
}
Quotes (1)
Analysis of Variance in Genetic Associations and Health Care Interventions
The maximal between-study variance was more likely to be recorded early in the 44 eligible meta-analyses of genetic associations than in the 37 meta-analyses of health care interventions (P = .013). At the time of the first heterogeneity assessment, the most favorable-ever result in support of a specific association was more likely to appear than the least favorable-ever result (22 vs. 10, P = .017); the opposite was seen at the second heterogeneity assessment (15 vs. 5, P = .031). Such a sequence of extreme opposite results was not seen in the clinical trials meta-analyses. The estimated between-study variance decreased over time in genetic association studies (P = .010), but not in clinical trials (P = .30).